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Related Experiment Video

Updated: May 12, 2026

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
08:35

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

Published on: May 26, 2022

Vascular and renal hemodynamic changes after renal denervation.

Christian Ott1, Rolf Janka, Axel Schmid

  • 1Department of Nephrology and Hypertension, University of Erlangen-Nuremberg, Erlangen, Germany.

Clinical Journal of the American Society of Nephrology : CJASN
|April 6, 2013
PubMed
Summary
This summary is machine-generated.

Renal denervation (RDN) effectively lowers blood pressure in resistant hypertension patients. This procedure reduced both peripheral and central blood pressure without impacting renal perfusion or function.

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Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension
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Area of Science:

  • Cardiovascular Medicine
  • Nephrology
  • Interventional Cardiology

Background:

  • Renal denervation (RDN) is a treatment for resistant hypertension.
  • RDN decreases sympathetic drive but its effects on renal hemodynamics are unknown.

Purpose of the Study:

  • To investigate the impact of RDN on renal perfusion, renal vascular resistance (RVR), and central hemodynamics.
  • To assess changes in renal function post-RDN.

Main Methods:

  • Nineteen patients with resistant hypertension underwent RDN.
  • Renal perfusion and RVR were measured using MRI with arterial spin labeling.
  • Central hemodynamics were assessed via pulse wave analysis.

Main Results:

  • RDN significantly reduced peripheral and central blood pressure (BP).
  • Renal perfusion and renal function remained unchanged post-RDN.
  • Renal vascular resistance (RVR) decreased significantly after RDN.

Conclusions:

  • RDN is effective in lowering both peripheral and central BP in resistant hypertension.
  • RDN does not adversely affect renal perfusion or function.