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Updated: May 12, 2026
09:47
Isolation, Processing and Analysis of Murine Gingival Cells
Published on: July 2, 2013
Gingival plasma cell granuloma
Amitkumar B Pandav1, Alka V Gosavi, Dhaneshwar N Lanjewar
1Department of Pathology, Government Medical College, Miraj, Maharashtra, India.
Dental Research Journal
|April 6, 2013
Summary
This study reports a rare gingival plasma cell granuloma, a benign inflammatory pseudotumor, in a woman. Histopathology confirmed a non-cancerous lesion with plasma cell infiltration.
Area of Science:
- Oral Pathology
- Oncology
- Immunohistochemistry
Background:
- Plasma cell granuloma (PCG), or inflammatory pseudotumor, typically affects the lungs but can occur in diverse locations.
- Gingival involvement is exceptionally rare, presenting diagnostic challenges.
Observation:
- A 58-year-old woman presented with a polypoidal growth on her upper gingiva.
- The lesion was surgically excised for diagnosis and treatment.
Findings:
- Histopathological examination revealed a benign proliferation of spindle mesenchymal cells within a fibrocollagenous stroma.
- Dense chronic inflammatory cell infiltrate, predominantly plasma cells, was observed.
- Immunohistochemistry demonstrated a polyclonal kappa and lambda light chain staining pattern, confirming PCG and excluding neoplastic processes.
Implications:
- This case highlights the importance of considering rare diagnoses like gingival PCG in oral lesions.
- Accurate histopathological and immunohistochemical analysis is crucial for correct diagnosis and patient management.
- Understanding the diverse manifestations of PCG aids in differential diagnosis of oral masses.
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