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Updated: May 12, 2026

MR Molecular Imaging of Prostate Cancer with a Small Molecular CLT1 Peptide Targeted Contrast Agent
Published on: September 3, 2013
T(2)-weighted combined with diffusion-weighted images for evaluating prostatic transition zone tumors at 3 Tesla
Jing Ren1, Yong Yang, Jinsong Zhang
1Department of Radiology, Xijing Hospital, Fourth Military Medical University, 15 Chang Le Western Road, Xi'an 710032, China.
Aim:
We hypothesize that the combination of T(2)-weighted (T(2)W) MRI with diffusion-weighted imaging (DWI) methods provides a powerful clinical application for the differential diagnosis of prostate cancer and benign lesion in the prostatic transition zone (TZ).
Methods:
This retrospective study included 113 patients who were diagnosed with TZ lesions by MRI. The apparent diffusion coefficient values were compared between biopsy-proven benign and malignant lesions.
Results:
The apparent diffusion coefficient values for the malignant nodules were significantly lower than those of the benign nodules. The area under the curve values for T(2)W imaging combined with DWI and T(2)W imaging alone were 0.991 and 0.884, respectively.
Conclusion:
T(2)W combined with DWI provides a powerful tool for noninvasive differentiation between malignant and benign prostatic hyperplasia nodules in the prostatic TZ.
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