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Fabrication of Size-Controlled and Emulsion-Free Chitosan-Genipin Microgels for Tissue Engineering Applications

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Nonionic polymer cross-linked chitosan hydrogel: preparation and bioevaluation.

Liangxin Xu¹, Xiaoyong Zhang, Chongyu Zhu

¹Department of Chemistry and the Tsinghua Center for Frontier Polymer Research, Tsinghua University, Beijing 100084, P.R. China.

Journal of Biomaterials Science. Polymer Edition

|April 9, 2013

Summary

A new chitosan-polyacrylamide (CS-PAM) hydrogel is easily prepared at room temperature. This biocompatible biomaterial shows minimal cytotoxicity and excellent hemocompatibility for potential healthcare applications.

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Preparation of Chitosan-based Injectable Hydrogels and Its Application in 3D Cell Culture

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Published on: September 29, 2017

Area of Science:

Biomaterials Science
Polymer Chemistry
Biomedical Engineering

Background:

Chitosan hydrogels are promising biomaterials.
Developing simple, biocompatible hydrogels is crucial for biomedical applications.

Purpose of the Study:

To develop a straightforward method for preparing chitosan-polyacrylamide (CS-PAM) hydrogel.
To evaluate the cytotoxicity and hemocompatibility of the novel CS-PAM hydrogel.

Main Methods:

Chitosan and polyacrylamide solutions were mixed at room temperature.
Cytotoxicity was assessed using A549 and HeLa cells.
Hemocompatibility was evaluated by incubating with red blood cells.

Main Results:

CS-PAM hydrogel was rapidly synthesized (<30s) under benign conditions.
Minimal cytotoxicity observed even at high concentrations (640 μg mL⁻¹).
No hemolysis occurred, indicating excellent hemocompatibility.

Conclusions:

The CS-PAM hydrogel offers a low-cost, easily prepared, and highly biocompatible material.
Its ability to interact with red blood cells suggests potential in blood-related biomedical applications.
This hydrogel shows significant promise for future healthcare innovations.