Related Experiment Video
Updated: May 12, 2026

Directed Differentiation of Induced Pluripotent Stem Cells towards T Lymphocytes
Published on: May 14, 2012
To be immunogenic, or not to be: that's the iPSC question
1Center for iPS Cell Research and Application, Kyoto University, Kyoto 606-8507, Japan. kaneko.shin@cira.kyoto-u.ac.jp
Abstract:
The unexpected finding that autologous induced pluripotent stem cell (iPSC)-derived teratomas are immunogenic in syngeneic hosts sparked pessimism over their therapeutic potential; however, two recent reports (Guha et al., 2013 and Araki et al., 2013; the latter in this issue of Cell stem cell) contradict previous findings, showing no immunogenicity of in vitro differentiated syngeneic iPS-derived cells and supporting their safety.
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