Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Tumorigenesis by a long wavelength UV-A source.

H J Sterenborg1, J C van der Leun

  • 1Laser Centre Academic Hospital, University of Amsterdam, The Netherlands.

Photochemistry and Photobiology
|March 1, 1990
PubMed
Summary

High-power long wavelength ultraviolet-A (UV-A) radiation induced tumors in albino hairless mice. Tumors developed in 31 of 48 mice, with a median induction time of 265 days.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The consequences for human health of stratospheric ozone depletion in association with other environmental factors.

Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology·2014
Same author

Pneumothorax monitoring by remittance measurement: comparison between experimental model and animal studies.

Lasers in medical science·2014
Same author

The human health effects of ozone depletion and interactions with climate change.

Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology·2011
Same author

Double-integrating-sphere system for measuring the optical properties of tissue.

Applied optics·2010
Same author

Continuous pneumothorax monitoring by remittance measurement.

Applied optics·2010
Same author

Quantification of the hematoporphyrin derivative by fluorescence measurementusing dual-wavelength excitation anddual-wavelength detection.

Applied optics·2010

Area of Science:

  • Dermatology
  • Oncology
  • Photobiology

Background:

  • Ultraviolet-A (UV-A) radiation is a component of sunlight.
  • The carcinogenic potential of UV-A is less understood than UV-B.
  • Hairless mice are a common model for skin research.

Purpose of the Study:

  • To investigate the tumorigenic effects of high-power, long-wavelength UV-A radiation.
  • To determine the latency period for UV-A-induced tumor formation.

Main Methods:

  • Albino hairless mice (Skh-hr1) were exposed to daily doses of UV-A radiation (220 kJ/m2) for 2 hours.
  • Tumor development was monitored over time.
  • Scratching behavior was also noted.

Main Results:

  • Tumors (≥1 mm) developed in 31 out of 48 mice.
  • The median induction time for 1 mm tumors was 265 days.
  • Scratching marks were observed in 13 mice, often after tumor development.

Conclusions:

  • High-power, long-wavelength UV-A radiation can induce skin tumors in mice.
  • UV-A radiation exposure presents a significant risk for skin carcinogenesis.
  • Further research is needed to understand the mechanisms of UV-A-induced skin damage and tumor formation.

Related Experiment Videos