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Prevalence of celiac disease in healthy Iranian school children

Seyed Mohsen Dehghani1, Mahmood Haghighat, Arash Mobayen

  • 1Shiraz University of Medical Sciences, Gastroenterohepatology Research Center, Shiraz Transplant Research Center, Shiraz 7193711351, Iran. dehghanism@sums.ac.ir

Annals of Saudi Medicine
|April 9, 2013
PubMed

Insights

Silent celiac disease, a hidden form of celiac disease, affects 0.6% of healthy children in Shiraz, Iran. Early diagnosis is crucial due to potential complications in these asymptomatic children.

Area of Science:

  • Pediatric Gastroenterology
  • Immunology
  • Public Health

Background:

  • Celiac disease often presents asymptomatically as silent celiac disease.
  • Silent celiac disease poses risks of complications, necessitating early detection.
  • Investigating the prevalence of silent celiac disease in pediatric populations is vital.

Purpose of the Study:

  • To determine the prevalence of silent celiac disease in healthy school-aged children in Shiraz, Iran.
  • To highlight the public health significance of undiagnosed celiac disease in children.

Main Methods:

  • A cross-sectional study was conducted involving 1500 healthy school children aged 6-12 years in Shiraz.
  • Serological testing for anti-tissue transglutaminase immunoglobulin A antibodies was performed.
  • Intestinal biopsies were obtained for positive serology cases, analyzed using modified Marsh criteria.

Main Results:

  • A 2% seropositivity rate for anti-tissue transglutaminase immunoglobulin A antibodies was observed.
  • The prevalence of biopsy-proven silent celiac disease was found to be 0.6%.
  • The mean age of participants was 9.5 years (SD 1.3).

Conclusions:

  • Silent celiac disease is prevalent in Shiraz, indicating a significant health concern.
  • The findings suggest a need for increased awareness and screening for celiac disease in children.
  • This study contributes to understanding the epidemiology of celiac disease in Southern Iran.
Abstract

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