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Related Concept Videos

Integrins01:10

Integrins

Animal and protozoan cells do not have cell walls to help maintain shape and provide structural stability. Instead, these eukaryotic cells secrete a sticky mass of carbohydrates and proteins into the spaces between adjacent cells. This network of proteins and molecules is called an extracellular matrix or ECM.
Some ECM proteins assemble into a basement membrane to which the remaining components adhere. Proteoglycans typically form the bulk of the ECM while fibrous proteins, like collagen,...
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Activation of Integrins01:15

Activation of Integrins

Integrins bind ligands and transmit information from outside the cell to inside or vice-versa through an "outside-in signaling" or "inside-out signaling."
In "outside-in signaling," external factors in the extracellular space bind to exposed ligand binding sites on integrins. This causes the inactive protein to undergo a conformational change to become active. Integrins are often clustered on the cell membrane. Repetitive and regularly spaced ligand binding events provide an effective stimulus.
Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
Selectins01:25

Selectins

Cell adhesion is  an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain, which...
Cancer Cell Migration through Invadopodia01:35

Cancer Cell Migration through Invadopodia

Invadosome is a broad category of cell surface structures with proteolytic activity that  degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However, invadopodia can...

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Related Experiment Video

Updated: May 12, 2026

Combined Use of Tail Vein Metastasis Assays and Real-Time In Vivo Imaging to Quantify Breast Cancer Metastatic Colonization and Burden in the Lungs
10:32

Combined Use of Tail Vein Metastasis Assays and Real-Time In Vivo Imaging to Quantify Breast Cancer Metastatic Colonization and Burden in the Lungs

Published on: December 19, 2019

Integrins and metastasis.

Kirat Kumar Ganguly1, Sekhar Pal, Shuvojit Moulik

  • 1Department of Receptor Biology & Tumor Metastasis, Chittaranjan National Cancer Institute, Kolkata, India.

Cell Adhesion & Migration
|April 9, 2013
PubMed
Summary
This summary is machine-generated.

Integrins are crucial for cancer metastasis, regulating cell adhesion and detachment. Targeting integrin biology offers promising strategies to combat cancer spread.

Keywords:
MMPadhesionintegrininvasionmetastasis

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Quantitative Analysis of Cancer Metastasis using an Avian Embryo Model
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Last Updated: May 12, 2026

Combined Use of Tail Vein Metastasis Assays and Real-Time In Vivo Imaging to Quantify Breast Cancer Metastatic Colonization and Burden in the Lungs
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Combined Use of Tail Vein Metastasis Assays and Real-Time In Vivo Imaging to Quantify Breast Cancer Metastatic Colonization and Burden in the Lungs

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Assessing Tumor Microenvironment of Metastasis Doorway-Mediated Vascular Permeability Associated with Cancer Cell Dissemination using Intravital Imaging and Fixed Tissue Analysis
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Quantitative Analysis of Cancer Metastasis using an Avian Embryo Model
08:40

Quantitative Analysis of Cancer Metastasis using an Avian Embryo Model

Published on: May 30, 2011

Area of Science:

  • Oncology
  • Cell Biology
  • Molecular Biology

Background:

  • Metastasis is a complex biological process distinguishing cancer from other diseases.
  • Key cellular activities like migration, invasion, survival, and proliferation are essential for metastasis.
  • Regulation of cell attachment and detachment is critical, involving integrin receptors.

Purpose of the Study:

  • To review the critical role of integrin biology in regulating cancer metastasis.
  • To explore therapeutic strategies targeting integrin receptors to control metastasis.

Main Methods:

  • Literature review of existing research on integrins and metastasis.
  • Analysis of studies demonstrating the interrelation between integrin function and metastatic processes.

Main Results:

  • Integrin receptors play a vital role in coordinating cellular events during metastasis.
  • Numerous studies highlight the significant impact of integrins on cancer cell behavior.
  • Integrin-focused approaches are emerging as key strategies in anti-metastasis research.

Conclusions:

  • Integrin biology is fundamental to the regulation of cancer metastasis.
  • Targeting integrin receptors presents a promising therapeutic avenue for controlling metastatic disease.