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Updated: May 12, 2026

Monitoring Protein Adsorption with Solid-state Nanopores

Monitoring Protein Adsorption with Solid-state Nanopores

Published on: December 2, 2011

Multiplexed ionic current sensing with glass nanopores.

Nicholas A W Bell¹, Vivek V Thacker, Silvia Hernández-Ainsa

¹Cavendish Laboratory, Cambridge, United Kingdom.

|April 9, 2013

Summary

This summary is machine-generated.

Researchers developed a low-cost method for simultaneous single-molecule detection using 16 solid-state nanopore channels. This technique enables multichannel ionic current measurements for DNA analysis and nanostructure trapping.

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Last Updated: May 12, 2026

Monitoring Protein Adsorption with Solid-state Nanopores

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Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles

Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles

Published on: March 13, 2017

Area of Science:

Nanotechnology
Biophysics
Analytical Chemistry

Background:

Single-molecule detection is crucial for understanding biological processes.
Solid-state nanopores offer a platform for label-free molecular analysis.
Current methods often lack high-throughput capabilities.

Purpose of the Study:

To develop a cost-effective, high-throughput method for simultaneous single-molecule measurements.
To demonstrate the utility of the developed system for DNA detection and nanostructure manipulation.

Main Methods:

Fabrication of microdevices with up to 16 glass nanopore channels using laser-assisted capillary pulling.
Simultaneous ionic current measurements across multiple nanopore channels.
Detection of double-stranded DNA (dsDNA) translocation events.
Trapping of DNA origami nanostructures to create hybrid nanopores.

Main Results:

Successful simultaneous ionic current measurements from 16 nanopore channels.
Demonstrated detection of dsDNA molecules in a multichannel setup.
Achieved stable trapping of DNA origami nanostructures, forming functional hybrid nanopores.
The developed devices are low-cost, with each unit costing less than $20.

Conclusions:

The developed multichannel nanopore system provides a scalable and affordable platform for single-molecule analysis.
This method significantly enhances throughput for nanopore-based sensing applications.
The ability to form hybrid nanopores opens new avenues for studying complex molecular interactions.