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Takotsubo cardiomyopathy in siblings

Masayasu Ikutomi1, Masao Yamasaki, Masashiro Matsusita

  • 1NTT Medical Center, 5-9-22 Higashi-Gotanda, Shinagawa-ku, Tokyo, 141-8625, Japan, mikutomi@gmail.com.

Heart and Vessels
|April 9, 2013
PubMed

Insights

Apical ballooning syndrome (ABS), also known as stress-induced cardiomyopathy, occurred in two sisters, suggesting a potential genetic link. This rare familial occurrence highlights the need for further investigation into the genetic factors of ABS.

Area of Science:

  • Cardiology
  • Genetics
  • Internal Medicine

Background:

  • Apical ballooning syndrome (ABS), or stress-induced cardiomyopathy, is an acute cardiac condition.
  • It is characterized by transient left ventricular dysfunction, typically in postmenopausal women.

Observation:

  • A 64-year-old woman presented with chest pain, ECG changes, and apical akinesis consistent with ABS.
  • Myocardial sympathetic denervation was observed in the apical region using [(123)I]metaiodobenzylguanidine.
  • Her elder sister had been diagnosed with ABS one year prior.

Findings:

  • This represents a rare familial case of apical ballooning syndrome.
  • Both affected individuals were postmenopausal females.
  • The co-occurrence in siblings suggests a possible genetic predisposition.

Implications:

  • Familial cases of ABS are exceedingly rare, prompting further research into genetic etiologies.
  • Understanding genetic factors may aid in predicting susceptibility and developing targeted therapies for ABS.
  • This case underscores the importance of considering familial patterns in the diagnosis and management of stress-induced cardiomyopathy.

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