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04:46
The Quantification of Injectability by Mechanical Testing
Published on: May 13, 2020
Premixed injectable calcium phosphate cement with excellent suspension stability
Fangping Chen1, Yuhao Mao, Changsheng Liu
1State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, People's Republic of China. chenfangping06@yahoo.com.cn
Journal of Materials Science. Materials in Medicine
|April 9, 2013
Summary
Premixed injectable calcium phosphate cement (p-ICPC) pastes stabilized with fumed silica offer improved storage stability and injectability. This biomaterial demonstrates good cytocompatibility, showing potential for future bone defect treatments.
Area of Science:
- Biomaterials Science
- Materials Chemistry
- Orthopedic Engineering
Background:
- Premixed injectable calcium phosphate cement (p-ICPC) offers advantages over aqueous formulations, including enhanced storage stability and controlled setting.
- Developing stable, injectable bone cements is crucial for minimally invasive orthopedic procedures and long-term storage.
- Fumed silica and propylene glycol (PEG) are explored as potential stabilizing agents and continuous phases for non-aqueous cement formulations.
Purpose of the Study:
- To evaluate the suspension stability of premixed injectable calcium phosphate cement (p-ICPC) paste using fumed silica as a stabilizer and PEG as the continuous phase.
- To assess the physicochemical properties, injectability, and in vitro cytocompatibility of the developed p-ICPC formulation.
Main Methods:
- Utilized multiple light scanning techniques to assess the suspension stability of p-ICPC pastes.
- Incorporated fumed silica as a stabilizing agent within a PEG continuous phase.
- Evaluated the hydration, thixotropy, compressive strength, injectability, and cytocompatibility (MG-63 cells) of the optimized p-ICPC formulation.
Main Results:
- Fumed silica significantly enhanced the suspension stability of p-ICPC pastes by forming a thixotropic network structure in PEG.
- The p-ICPC formulation exhibited proper thixotropy, good compressive strength, and excellent injectability.
- In vitro studies confirmed the cytocompatibility of the p-ICPC, showing no adverse effects on MG-63 cell attachment and proliferation.
Conclusions:
- Fumed silica effectively stabilizes premixed injectable calcium phosphate cement (p-ICPC) in a propylene glycol (PEG) medium, enabling long-term storage and controlled application.
- The developed p-ICPC demonstrates favorable mechanical properties, injectability, and cytocompatibility, making it a promising candidate for bone regeneration.
- This approach may guide the development of other non-aqueous injectable biomaterials for delayed clinical use.
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