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Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Published on: February 9, 2011

Community-associated methicillin-resistant staphylococcus aureus epidemic clone USA100; more than a nosocomial

Jill C Roberts1

  • 1Department of Environmental and Occupational Health, University of South Florida, College of Public Health, Tampa, FL 33612 USA.

Springerplus
|April 9, 2013
PubMed
Abstract

Insights

Community-acquired Methicillin-Resistant Staphylococcus aureus (MRSA) USA100 strains show genetic diversity and carry virulence genes. Nasal carriage is important for the spread of these epidemic MRSA strains in the community.

Area of Science:

  • Microbiology
  • Epidemiology
  • Genetics

Background:

  • Characterization of 100 USA100 epidemic Methicillin-Resistant Staphylococcus aureus (MRSA) strains.
  • Focus on community-associated isolates with no healthcare risk factors.

Observation:

  • Molecular epidemiology revealed 21 pulsed-field types and six spa types.
  • All strains harbored the type II staphylococcal cassette chromosome mec (SCCmec).
  • The staphylococcal enterotoxin D virulence gene was consistently detected.

Findings:

  • USA100 MRSA strains in the community exhibit significant genetic diversity.
  • Presence of type II SCCmec and staphylococcal enterotoxin D gene in all isolates.
  • Identification of multiple pulsed-field and spa types indicates clonal evolution.

Implications:

  • Highlights the importance of nasal carriage in the transmission of community-associated MRSA.
  • Suggests USA100 MRSA is an evolving clone with diverse genetic makeup.
  • Informs public health strategies for controlling MRSA spread in community settings.
Keywords:
MRSAPFGESpaStaphylococcusUSA100

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