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Pediatric Cushing's disease: Management Issues

Martin O Savage1, Helen L Storr

  • 1Department of Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, London, UK.

Indian Journal of Endocrinology and Metabolism
|April 9, 2013
PubMed

Insights

Cushing's disease (CD) in children, though rare, presents diagnostic and therapeutic challenges. This study outlines a protocol for diagnosing and managing pediatric CD, aiding endocrinologists.

Area of Science:

  • Pediatric Endocrinology
  • Neuroendocrinology
  • Oncology

Background:

  • Cushing's disease (CD) in children is rare, caused by ACTH-secreting pituitary adenomas.
  • It presents unique diagnostic and therapeutic challenges for pediatric endocrinologists.
  • Key symptoms include weight gain, growth failure, and altered facial appearance.

Purpose of the Study:

  • To describe a diagnostic protocol for pediatric Cushing's disease.
  • To examine and appraise treatment strategies for pediatric CD.
  • To discuss the post-cure management of pediatric CD patients.

Main Methods:

  • The diagnostic protocol follows the established model for adult patients.
  • Treatment strategies are critically reviewed and evaluated.
  • Long-term management following successful treatment is considered.

Main Results:

  • A structured diagnostic approach is proposed for pediatric CD.
  • Current treatment options are appraised for efficacy and safety.
  • Guidelines for long-term follow-up are discussed.

Conclusions:

  • Pediatric Cushing's disease requires specialized diagnostic and management approaches.
  • Consultation with adult endocrinology colleagues is beneficial.
  • A defined protocol can improve patient outcomes.

Keywords:
Cushing's diseaseCushing's syndromepediatricsradiotherapytranssphenoidal surgery

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