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Related Concept Videos

iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...

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Related Experiment Video

Updated: May 12, 2026

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers
04:09

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers

Published on: March 3, 2023

Stem cell therapy for diabetes.

K O Lee1, S U Gan, R Y Calne

  • 1Department of Medicine, National University of Singapore, Singapore.

Indian Journal of Endocrinology and Metabolism
|April 9, 2013
PubMed
Summary
This summary is machine-generated.

Stem cell therapy offers hope for diabetes mellitus treatment. Research explores alternatives like induced pluripotent stem cells for safer, effective diabetes management strategies.

Keywords:
Embryonic stem celldiabetesinduced pluripotent stem cellmesenchymal stem cell

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Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers
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Area of Science:

  • Regenerative Medicine
  • Endocrinology
  • Cell Biology

Background:

  • Diabetes mellitus poses a significant global health challenge.
  • Human embryonic stem cells (hESCs) show potential for differentiating into insulin-producing islet cells.
  • Clinical use of hESCs is hindered by ethical issues and teratoma risk.

Purpose of the Study:

  • To review the current state of stem cell therapy for diabetes mellitus.
  • To explore alternative stem cell sources beyond hESCs.
  • To assess the future potential of stem cell-based treatments for diabetes.

Main Methods:

  • Review of existing research on stem cell differentiation for diabetes.
  • Analysis of developmental stages and transcription factors in islet cell formation.
  • Evaluation of alternative stem cell types: induced pluripotent stem cells (iPSCs), umbilical cord stem cells (UCSCs), and bone marrow-derived mesenchymal stem cells (BM-MSCs).

Main Results:

  • Understanding of hESC differentiation pathways into islet cells has advanced.
  • Ethical concerns and safety (teratoma formation) limit hESC clinical application.
  • iPSCs, UCSCs, and BM-MSCs are under intense investigation as viable alternatives.

Conclusions:

  • Stem cell research is pivotal for developing novel diabetes mellitus treatments.
  • Alternative stem cell sources show promise for overcoming hESC limitations.
  • Advancements suggest stem cell therapy could become a realistic future treatment for diabetes.