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Human epidermal growth factor receptor 2-targeted therapies in breast cancer

Rita Nahta

    Expert Opinion on Biological Therapy
    |April 10, 2013
    PubMed

    Insights

    Future research into how cancer cells evade human epidermal growth factor receptor 2 (HER2) targeted therapies is crucial. Understanding resistance mechanisms will enable personalized treatment selection for HER2-positive breast cancer patients.

    Area of Science:

    • Oncology
    • Molecular Biology
    • Translational Research

    Background:

    • Human epidermal growth factor receptor 2 (HER2) has been a key therapeutic target in breast cancer for over 25 years.
    • Four HER2-targeted therapies have been approved in the last 15 years, stemming from significant basic science and translational discoveries.
    • Despite advances, challenges remain in optimizing treatment selection for HER2-positive breast cancer.

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