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Opportunistic viral infections in intestinal transplantation

Diana F Florescu1, Alan N Langnas, Uriel Sandkovsky

  • 1Division of Infectious Diseases, Transplant Infectious Diseases Program, University of Nebraska Medical Center, Omaha, NE 68198-5400, USA. dflorescu@unmc.edu

Expert Review of Anti-Infective Therapy
|April 10, 2013
PubMed

Insights

Intestinal transplantation (IT) is a vital treatment for intestinal failure, with survival rates improving over time. However, infections remain a significant challenge, impacting patient morbidity and mortality post-transplant.

Area of Science:

  • Gastroenterology and Hepatology
  • Transplant Surgery
  • Pediatric Surgery

Background:

  • Intestinal transplantation (IT) is an established therapy for intestinal failure and complications from parenteral nutrition.
  • The number of IT recipients has gradually increased over the past 20 years.
  • Children under 10 years old constitute a significant portion of IT recipients.

Purpose of the Study:

  • To review the trends and outcomes of intestinal transplantation.
  • To highlight the survival rates and major complications associated with IT.

Main Methods:

  • Analysis of data from intestinal transplant procedures performed between January 1, 1990, and March 31, 2012.
  • Examination of survival rates at 1, 5, and 10 years post-transplantation.
  • Identification of primary causes of morbidity and mortality.

Main Results:

  • A total of 2191 ITs were performed during the study period.
  • Survival rates at 1, 5, and 10 years were 78.5%, 58.2%, and 47%, respectively.
  • Infections were identified as the leading cause of complications, morbidity, and mortality.

Conclusions:

  • Intestinal transplantation is a life-restoring procedure for patients with intestinal failure.
  • While IT offers functional recovery, managing post-transplant infections is critical for improving long-term outcomes.
  • Continued research is needed to mitigate infection-related complications in IT recipients.

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