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Updated: Feb 7, 2026
One-anastomosis Gastric Bypass OAGB in Rats
Published on: November 10, 2018
Gastric bypass reversal in patients with short bowel syndrome
Jon S Thompson1, Fedja A Rochling2, Elizabeth Lyden3
1Department of Surgery, University of Nebraska Medical Center, Omaha, NE, USA.
Background:
5-10 % patients developing short bowel syndrome (SBS) have undergone a previous gastric bypass (GBP) for morbid obesity. The benefits of restoring gastric anatomy in these patients is assumed but remains unclear. Our aim was to determine the effect of gastric bypass reversal on parenteral nutrition (PN) dependence in patients developing SBS following GBP.
Materials And Methods:
We reviewed 44 adults with SBS who had undergone GBP prior to SBS. There were 4 groups based on timing of reversal: reversal when developing SBS (n = 11), within 22 months of SBS (n = 13), greater than 22 months after SBS (n = 11), and an intact GBP (n = 9).
Results:
Thirty five (80 %) patients had reversal of the GBP. Nine (20 %) patients had an intact GBP, including five who underwent distal gastrectomy. Eleven (25 %) patients had bypass reversal at the time of developing SBS. There was no significant difference in PN independence at 22 months with or without GBP reversal (25 % versus 15 %). Three patients undergoing reversal 22 months after developing SBS were weaned from PN.
Conclusions:
The majority of patients who develop SBS following GBP for morbid obesity have the procedure reversed. The timing of reversal does not appear to be important in nutritional outcome. We were unable to determine that GPB reversal is associated with increased PN independence.
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