Related Experiment Video
Updated: May 12, 2026

12:08
Improving IV Insulin Administration in a Community Hospital
Published on: June 11, 2012
The future is now: software-guided intensive insulin therapy in the critically ill
Rishi Rattan1, Stanley A Nasraway
1Tufts Medical Center, Boston, MA 02111, USA.
Journal of Diabetes Science and Technology
|April 10, 2013
Summary
Software-guided (SG) algorithms offer a new approach to tight glycemic control (TGC) in critically ill adults. Further standardization of measurements and variables is needed for improved algorithm development and clinical implementation.
Area of Science:
- Critical care medicine
- Endocrinology
- Biomedical informatics
Background:
- Intensive insulin therapy in critically ill adults presents challenges for achieving tight glycemic control (TGC).
- Software-guided (SG) algorithms are emerging as a novel method for glycemic management in critical illness.
Purpose of the Study:
- To provide an overview of the current status of software-guided tight glycemic control (SG TGC) in critical care.
- To identify future directions and necessary advancements for SG TGC algorithms.
Main Methods:
- Review of the current landscape of software-guided algorithms for insulin dosing in critically ill patients.
- Analysis of existing research on tight glycemic control and its complexities.
Main Results:
- The current field of SG TGC is characterized by disorganization and a lack of research incorporating advanced glycemic variables.
- Glycemic variability is an underutilized variable in current dysglycemia management strategies.
Conclusions:
- Standardization of measurements and variables is crucial for the development and implementation of more effective SG TGC algorithms.
- Interdisciplinary collaboration among scientists, programmers, and clinicians is essential for advancing SG TGC.
Related Concept Videos
Insulin Formulations: Types and Delivery
Insulin preparations are categorized by their duration of action into short-acting and long-acting types. Two strategies are used to modify insulin's absorption and pharmacokinetic profile: slowing the absorption post-subcutaneous injection, or altering human insulin's amino acid sequence or protein structure. These changes retain the insulin's ability to bind to the insulin receptor, but alter its behavior in solution or after injection.
Short-acting insulins are divided into rapid-acting...
Short-acting insulins are divided into rapid-acting...
Insulin: Dosing Regimen and Adverse Effects
Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
Diabetic Ketoacidosis l: Introduction
DefinitionDiabetic ketoacidosis (DKA) is an acute, life-threatening complication of diabetes mellitus, characterized by a triad of hyperglycemia (blood glucose >250 mg/dL), ketonemia or ketonuria, and metabolic acidosis (arterial pH <7.30 and serum bicarbonate <18 mEq/L). It results from insulin deficiency combined with elevated levels of counterregulatory hormones—glucagon, catecholamines, cortisol, and growth hormone—leading to increased lipolysis, hepatic ketone production, and...
Diabetes: Management and Pharmacotherapy
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Nursing Clinical Information System
Nursing Clinical Information System (NCIS)
A Nursing Clinical Information System (NCIS) is a specialized type of healthcare information system tailored to meet the unique needs of nursing practice. It incorporates the principles of nursing informatics to streamline information management and improve the quality of care delivery.
Critical attributes of NCIS include:
A Nursing Clinical Information System (NCIS) is a specialized type of healthcare information system tailored to meet the unique needs of nursing practice. It incorporates the principles of nursing informatics to streamline information management and improve the quality of care delivery.
Critical attributes of NCIS include:
Type I Diabetes I: Introduction
Type 1 diabetes mellitus is a chronic metabolic disorder characterized by an absolute deficiency of insulin resulting from the autoimmune destruction of pancreatic β-cells. Although it can occur at any age, it is most commonly diagnosed in childhood, adolescence, or early adulthood. The loss of insulin production impairs cellular glucose uptake, resulting in persistent hyperglycemia and necessitating lifelong insulin therapy.Autoimmune Destruction of β-CellsThe hallmark of type 1 diabetes is an...
