Related Experiment Video
Updated: May 12, 2026
04:33
Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder
Published on: April 26, 2024
Cognitive impairment in euthymic older adults with bipolar disorder: a controlled study using cognitive screening
Ivan Aprahamian1, Rodolfo B Ladeira1, Breno S Diniz1
1Laboratory of Neuroscience (LIM-27), Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Brazil.
Summary
Older adults with bipolar disorder (BD) show worse performance on cognitive screening tests compared to those without BD. This includes tests for memory and executive function across various cognitive levels.
Area of Science:
- Neuroscience
- Gerontology
- Psychiatry
Background:
- Cognitive impairment is prevalent in bipolar disorder (BD).
- Older adults with BD have an elevated risk of dementia.
- This study examines cognitive screening in older BD patients.
Purpose of the Study:
- To compare cognitive screening test performance in older adults with and without BD.
- To assess cognitive function across different impairment levels (normal, mild, dementia).
Main Methods:
- 186 older adults (86 BD, 100 controls) were assessed.
- Participants were stratified into normal cognition, cognitive impairment no dementia (CIND), and Alzheimer disease (AD) groups.
- Performance on Mini-Mental State Examination (MMSE), verbal fluency test (VFT), and Clock Drawing Test (CDT) was compared between BD and non-BD groups.
Main Results:
- Non-demented BD patients scored lower on MMSE and VFT compared to controls.
- BD patients with dementia performed significantly worse on the CDT than AD patients.
- BD patients demonstrated poorer performance on specific cognitive screening tests.
Conclusions:
- Older adults with BD exhibit significantly worse performance on certain cognitive screening tests.
- These deficits are observed across varying cognitive function levels.
- Findings highlight the impact of BD on cognitive health in aging populations.
More Related Videos
Related Concept Videos
01:30Bipolar Disorder
Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
01:30Cognitive Development During Adulthood
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
01:24Mania and Antimanic Drugs: Overview
Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as a...
01:30Negative and Cognitive Symptoms of Schizophrenia
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...