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Updated: May 12, 2026
10:44
Generating Whole Bacterial Genomes from Clinical Samples using a Target Enrichment Workflow
Published on: August 15, 2025
Genome comparisons as a tool for antimicrobial target discovery.
Hong Sun1, Hai-Feng Chen, Runsheng Chen
1Shanghai Center for Bioinformation Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
Methods in Molecular Biology (Clifton, N.J.)
|April 10, 2013
Summary
Comparing microbial and eukaryote genomes helps identify essential genes for drug discovery. Web tools streamline the analysis of homologous proteins and gene families for new antimicrobial targets.
Area of Science:
- Genomics
- Bioinformatics
- Drug Discovery
Background:
- Essential genes are often conserved across bacterial species.
- Genome comparisons between microbes and eukaryotes facilitate the identification of homologous proteins and families.
- These conserved elements represent potential targets for novel therapeutics.
Purpose of the Study:
- To summarize available Web resources for comparative genomics.
- To explain the step-by-step utilization of these computational tools.
- To facilitate the identification of antimicrobial drug targets.
Main Methods:
- Utilizing comparative genomics approaches.
- Leveraging Web-based tools for sequence information and analysis.
- Compiling datasets of homologous proteins and gene families.
Main Results:
- A curated list of Web resources for comparative genomic analysis is presented.
- Detailed instructions for using these tools are provided.
- The study highlights the utility of these resources in identifying potential drug targets.
Conclusions:
- Comparative genomics using Web tools is an efficient strategy for identifying essential genes.
- This approach aids in the discovery of novel antimicrobial agents and other drugs.
- Accessible computational tools enhance the process of target identification in drug design.
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