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Karyotyping

Karyotyping

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Related Experiment Video

Updated: May 12, 2026

Chromosome Screening of Human Preimplantation Embryos by Using Spent Culture Medium: Sample Collection and Chromosomal Ploidy Analysis

Chromosome Screening of Human Preimplantation Embryos by Using Spent Culture Medium: Sample Collection and Chromosomal Ploidy Analysis

Published on: September 7, 2021

[Karyotype analysis using cells cultured from fetal bladder centesis].

Jian Gao¹, Li-min Rong, Bing Mei

¹Hebei General Hospital, Shijiazhuang, P.R. China. gaojian8703@163.com

Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics

|April 10, 2013

Summary

Fetal bladder cells cultured from bladder centesis samples are feasible for karyotype analysis. This method allows prenatal chromosome analysis in early-gestation fetuses with giant bladder and oligohydramnios.

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Last Updated: May 12, 2026

Chromosome Screening of Human Preimplantation Embryos by Using Spent Culture Medium: Sample Collection and Chromosomal Ploidy Analysis

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Published on: September 7, 2021

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Culture of Bladder Cancer Organoids as Precision Medicine Tools

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Published on: December 28, 2021

Area of Science:

Prenatal diagnostics
Cytogenetics
Fetal medicine

Context:

Fetal bladder centesis is a minimally invasive procedure.
Giant bladder and oligohydramnios can complicate prenatal diagnosis.
Karyotype analysis is crucial for identifying chromosomal abnormalities.

Purpose:

To assess the feasibility of karyotype analysis using fetal bladder cells.
To establish an alternative method for prenatal chromosome analysis.

Summary:

Cells were successfully cultured from fetal bladder centesis samples of three fetuses with giant bladder and oligohydramnios.
Sufficient metaphase cells were obtained for successful chromosome counting and karyotype analysis.
The karyotypes of the three fetuses were determined.

Impact:

This technique offers a viable option for prenatal chromosome analysis in early gestation.
It is particularly beneficial for fetuses with specific conditions like giant bladder and oligohydramnios.
Expands the possibilities for genetic screening in challenging prenatal cases.