Related Experiment Video
Updated: May 12, 2026

10:12
Experimental Infection of Mice with the Parasitic Nematode Strongyloides ratti
Published on: January 17, 2025
Gastric strongyloidiasis as multiple small gastric nodules
Afshin Shafaghi1, Kurosh Askari, Hadi Hajizadeh
1Gastrointestinal and Liver Diseases Research Center (GLDRC), Rasht, Iran.
The American Journal of Case Reports
|April 10, 2013
Summary
Strongyloidiasis, a parasitic infection, can affect the stomach, causing nonspecific symptoms. Early diagnosis and treatment with Ivermectin are crucial for recovery, especially in endemic regions.
Area of Science:
- Gastroenterology
- Infectious Diseases
- Parasitology
Background:
- Strongyloidiasis is a parasitic infection prevalent in tropical and subtropical areas, with notable endemicity in Guilan province, Iran.
- The infection often affects rural populations and can present with nonspecific gastrointestinal symptoms, leading to delayed diagnosis.
Purpose of the Study:
- To report a case of gastric Strongyloidiasis presenting with chronic dyspepsia and epigastric pain.
- To highlight the importance of considering gastric involvement in Strongyloidiasis, particularly in endemic regions.
Main Methods:
- A case study of a 43-year-old woman with persistent upper gastrointestinal symptoms.
- Diagnostic procedures included upper gastrointestinal endoscopy revealing gastric nodules.
- Pathological examination confirmed Strongyloides infection.
Main Results:
- The patient presented with dyspepsia and epigastric pain unresponsive to standard treatments.
- Endoscopy revealed multiple small nodules in the stomach, diagnosed as Strongyloides.
- Treatment with Ivermectin and antibiotics resulted in complete resolution of symptoms and endoscopic findings.
Conclusions:
- Gastric involvement in Strongyloidiasis can manifest with nonspecific symptoms.
- Clinicians in endemic areas should consider Strongyloidiasis in the differential diagnosis of unexplained gastrointestinal complaints.
- Prompt diagnosis and appropriate treatment, such as with Ivermectin, are effective in managing gastric Strongyloidiasis.
Related Concept Videos
Histology of the Small Intestine
The small intestine exhibits a unique histological structure that significantly enhances its function in digestion and nutrient absorption. These structures include circular folds, villi, and various specialized cells that collectively facilitate the digestion of food.
The intestinal lining features transverse folds called circular folds, each housing fingerlike projections known as intestinal villi. These villi are covered by a layer of simple columnar epithelium, also referred to as...
The intestinal lining features transverse folds called circular folds, each housing fingerlike projections known as intestinal villi. These villi are covered by a layer of simple columnar epithelium, also referred to as...
Gastritis II: Pathophysiology
The pathophysiology of gastritis begins with the colonization of the stomach lining by Helicobacter pylori (H. pylori). This bacterium spreads mainly via the oral-oral route through saliva or shared utensils, and can also be transmitted in overcrowded or unhygienic environments through contaminated water, despite its brief survival outside the body.ColonizationOnce ingested, H. pylori enters the stomach and begins colonization by navigating through the mucus layer lining the stomach wall. It...
Pyloric Obstruction
Pyloric obstruction, also referred to as gastric outlet obstruction, is a condition characterized by narrowing or blockage at the pylorus—the muscular valve regulating the flow of stomach contents into the duodenum. When this passage becomes impaired, the stomach cannot effectively empty its contents into the small intestine. This disruption leads to a range of gastrointestinal symptoms, including early satiety, bloating, epigastric pain, postprandial nausea, persistent vomiting, and...
Gastritis-II: Pathophysiology
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies
Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
Peptic Ulcer
Peptic ulcers are erosive lesions of the gastric or duodenal lining, most commonly caused by Helicobacter pylori infection. This Gram-negative, helical bacterium has adapted to survive the stomach’s acidic environment by producing urease, which converts urea into ammonia and carbon dioxide. The ammonia neutralizes gastric acid in the bacterium’s immediate environment, allowing colonization of the gastric mucosa. H. pylori attaches to mucus-secreting epithelial cells, penetrates the mucus...