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Crayfish-related Haff disease rhabdomyolysis; diagnosis supported by bone scintigraphy

Peng Xie1, Jing Hu, Jian-Min Huang

  • 1Department of Nuclear Medicine, The Third Hospital, Hebei Medical University, NO. 139, Zi-Qiang Road, Shijiazhuang, Hebei Province, 050051, People's Republic of China. woxinfly1982@126.com

Hellenic Journal of Nuclear Medicine
|April 10, 2013
PubMed

Insights

Eating crayfish can cause rhabdomyolysis, a rare condition known as Haff disease. Bone imaging aids in diagnosing Haff disease by pinpointing muscle damage.

Area of Science:

  • Toxicology
  • Neurology
  • Pathology

Background:

  • Haff disease is a rare condition linked to consuming certain fish or crayfish.
  • It causes rhabdomyolysis, characterized by muscle breakdown.

Observation:

  • A 26-year-old man experienced severe, widespread muscle soreness for three months after eating crayfish.
  • Blood tests revealed elevated creatine kinase and lactate dehydrogenase levels.
  • Muscle biopsy confirmed rhabdomyolysis.

Findings:

  • Technetium-99m-methylene diphosphonate ((99m)Tc-MDP) whole body bone scintigraphy showed increased uptake in most muscles, particularly in the proximal extremities.
  • The patient's clinical presentation, histology, and imaging findings supported a diagnosis of Haff disease.

Implications:

  • This case highlights the utility of bone imaging in diagnosing Haff disease.
  • Bone scintigraphy can effectively identify and localize muscle damage in Haff disease patients.

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