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Related Experiment Video

Updated: May 12, 2026

Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures
06:32

Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures

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[Biomarkers in solid tumors].

Zsuzsanna Nagy1

  • 1Patológiai Tudományok Doktori Iskolája, Semmelweis Egyetem, Budapest, Hungary. zsulacz@chello.hu

Magyar Onkologia
|April 11, 2013
PubMed
Summary
This summary is machine-generated.

Molecular diagnostics advance cancer care. Anti-EGFR therapy benefits KRAS wild-type patients, while D-dimer shows prognostic value in multiple cancers, aiding personalized treatment strategies.

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Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Diagnostics

Background:

  • Molecular technology advancements have significantly improved cancer knowledge.
  • Understanding key molecular changes in cancer is crucial for diagnostics and therapy.
  • Identifying molecular targets and biomarkers for patient selection and prognosis is a major research challenge.

Purpose of the Study:

  • To investigate the role of biomarkers in predicting therapeutic response and prognosis.
  • To evaluate the effectiveness of anti-EGFR therapy in relation to KRAS mutations.
  • To explore the utility of D-dimer as a prognostic marker in various cancers.

Main Methods:

  • Analysis of anti-EGFR therapy response in patients with wild-type KRAS.
  • Immunohistochemical (IHC) analysis of colorectal cancer samples using tissue microarray.

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  • Assessment of D-dimer levels in early-stage tumor growth for breast, colorectal, and ovarian cancers.

    • Main Results:

    • Anti-EGFR therapy showed clinical benefit in 36% of wild-type KRAS patients; G13D mutations were frequent among KRAS-mutants.
    • IHC analysis revealed the EGFR signaling pathway is active in colon cancer, with increased downstream activity.
    • D-dimer levels increased in early tumor stages, comparable to classical tumor markers, and showed prognostic value.

    Conclusions:

    • KRAS wild-type status is a predictor for anti-EGFR therapy response.
    • The EGFR pathway is a viable target in colorectal cancer, and D-dimer is a potential prognostic biomarker.
    • These findings support the development of individualized and more effective antitumor strategies.