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Proteomics

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...

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Related Experiment Video

Updated: May 12, 2026

An Economical and Versatile High-Throughput Protein Purification System Using a Multi-Column Plate Adapter

An Economical and Versatile High-Throughput Protein Purification System Using a Multi-Column Plate Adapter

Published on: May 21, 2021

High throughput protein production for functional proteomics.

Pascal Braun¹, Josh LaBaer

¹Harvard University, Department for Chemistry and Chemical Biology, 12 Oxford Street, Cambridge, MA 02138, USA. pbraun@hms.harvard.edu

Drug Discovery Today

|April 12, 2013

Summary

This summary is machine-generated.

Genome projects enhance understanding of protein function for human health. Developing high-throughput (HT) protein expression systems is crucial for systematic, large-scale functional studies in the post-genomic era.

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Probing High-density Functional Protein Microarrays to Detect Protein-protein Interactions

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Published on: August 2, 2015

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Last Updated: May 12, 2026

An Economical and Versatile High-Throughput Protein Purification System Using a Multi-Column Plate Adapter

An Economical and Versatile High-Throughput Protein Purification System Using a Multi-Column Plate Adapter

Published on: May 21, 2021

Probing High-density Functional Protein Microarrays to Detect Protein-protein Interactions

Probing High-density Functional Protein Microarrays to Detect Protein-protein Interactions

Published on: August 2, 2015

Area of Science:

Molecular Biology
Genomics
Proteomics

Background:

Genome projects are revolutionizing human health by advancing the understanding of protein function.
Proteins are central to biological systems and therapeutic interventions, making their study critical.
The post-genomic era necessitates high-throughput (HT) methods for protein investigation.

Purpose of the Study:

To address the need for scalable protein isolation methods.
To describe the challenges and strategies in developing proteome-scale protein expression systems.

Main Methods:

Development of high-throughput (HT) protein expression systems.
Systematic investigation of protein function using purified proteins.
Utilizing large cDNA collections and novel protein-coding sequences.

Main Results:

Identified challenges in developing proteome-scale protein expression.
Outlined approaches for overcoming these challenges.
Facilitated large-scale functional protein studies.

Conclusions:

High-throughput protein expression systems are essential for post-genomic research.
Advancements in protein isolation methods are key to understanding protein function.
Proteome-scale expression systems enable systematic and large-scale biological investigations.