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Updated: May 12, 2026

Electron Spin Resonance Micro-imaging of Live Species for Oxygen Mapping
Published on: August 26, 2010
A europium(III)-based PARACEST agent for sensing singlet oxygen by MRI
Bo Song1, Yunkou Wu, Mengxiao Yu
1Department of Chemistry, University of Texas at Dallas, 800 West Campbell Road, Richardson, TX 75080, USA.
Abstract:
A europium(III) DOTA-tetraamide complex was designed as a MRI sensor of singlet oxygen ((1)O2). The water soluble, thermodynamically stable complex reacts rapidly with (1)O2 to form an endoperoxide derivative that results in an ∼3 ppm shift in the position of the Eu(III)-bound water chemical exchange saturation transfer (CEST) peak. The potential of using this probe to detect accumulation of the endoperoxide derivative in biological media by ratiometric CEST imaging was demonstrated.

