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Updated: May 12, 2026

Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
Published on: November 30, 2022
Arylboronic acid chemistry under electrospray conditions
Lifang Wang1, Chaofeng Dai, Sarah Kathryn Burroughs
1Department of Chemistry, Center for Diagnostics and Therapeutics, Georgia State University, P.O. Box 4098, Atlanta, GA 30302-4098, USA.
Abstract:
Boronic acids are important in the organic and biological arenas. Thus, their identification and characterization are important. ESI-MS is a well-known tool for such uses. Herein we report a systematic analysis of the chemical behavior of arylboronic acids under ESI-MS conditions. Such information will be very critical to understanding the gas-phase chemistry of boronic acids in an ESI mass spectrometer ion source in general and the MS analysis of boronic acids and their macromolecular conjugates in particular.
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