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Updated: May 12, 2026

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Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
Published on: November 12, 2015
Adjuvant corneal crosslinking to prevent hyperopic LASIK regression.
Ioannis M Aslanides1, Achyut N Mukherjee
1Emmetropia Mediterranean Eye Clinic, Heraklion, Crete, Greece.
Clinical Ophthalmology (Auckland, N.Z.)
|April 12, 2013
Summary
Simultaneous hyperopic laser assisted in situ keratomileusis (LASIK) and corneal crosslinking (CXL) appears safe and effective for long-term hyperopic correction. This combined approach shows promise in preventing regression and addressing ectasia risk.
Area of Science:
- Ophthalmology
- Refractive Surgery
- Corneal Biomechanics
Background:
- Hyperopic refractive errors can lead to regression after LASIK.
- Corneal ectasia is a potential risk following refractive surgery.
- Corneal crosslinking (CXL) enhances corneal biomechanical strength.
Purpose of the Study:
- To evaluate the long-term outcomes, safety, stability, and efficacy of simultaneous hyperopic LASIK and CXL.
- To assess the potential of this combined procedure in managing hyperopic regression and ectasia risk.
Main Methods:
- A pilot series of five eyes underwent simultaneous LASIK and CXL for hyperopia.
- Riboflavin was applied under the LASIK flap, followed by UV irradiation.
- Outcomes were assessed at multiple time points up to 4 years and compared to a LASIK-only cohort.
Main Results:
- All eyes in the LASIK-CXL group maintained refractive stability over 4 years.
- No complications related to CXL were observed.
- Topographic and clinical outcomes were comparable to standard LASIK.
Conclusions:
- Simultaneous LASIK and CXL for hyperopia is a safe procedure.
- This technique shows potential for reducing hyperopic regression, likely due to biomechanical stabilization.
- The combined approach may offer a solution for managing ectasia risk in hyperopic patients.
Keywords:
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