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Tardive dyskinesia induced by sulpiride
A Achiron1, Y Zoldan, E Melamed
1Department of Neurology, Beilinson Medical Center, Petach-Tiqva, Israel.
Clinical Neuropharmacology
|June 1, 1990
Summary
Tardive dyskinesia, a rare side effect of sulpiride, can occur during or after treatment. This selective D2-receptor antagonist requires cautious administration due to potential involuntary movements.
Area of Science:
- Neuroscience
- Pharmacology
- Clinical Medicine
Background:
- Tardive dyskinesia (TD) is an established adverse effect of traditional neuroleptics.
- Sulpiride, a selective D2-receptor antagonist, has rarely been associated with TD.
Observation:
- Six patients developed TD after sulpiride treatment for depression or gastrointestinal issues.
- Involuntary movements appeared during treatment in three patients and after discontinuation in three others.
Findings:
- These cases confirm sulpiride as a potential cause of tardive dyskinesia.
- The onset of TD can be delayed even after sulpiride cessation.
Implications:
- Clinicians should exercise caution when prescribing sulpiride.
- Increased awareness of sulpiride-induced TD is warranted for early detection and management.