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The Relationship between Salivary Beta-2 Microglobulin and Uremia Intensity in Men with Chronic Renal Failure
Mohammad Vahedi1, Hossein Malekzadeh, Habib Haybar
11. Department of Oral Medicine, Dental Research Center, School of Dentistry, Hamadan University of Medical Sciences, Hamadan, Iran.
Objective:
This study defines the relationship between salivary beta-2 microglobulin (β2-M) and intensity of uremia in male patients diagnosed with chronic renal failure (CRF).
Materials And Methods:
In total of 42 males were enrolled in a case-control study. There were 21 cases of CRF and 21 control cases. We collected 10cc of saliva plus 5 cc of blood from all patients to determine β2-M, blood urea nitrogen (BUN) and creatinine (Cr) levels.
Results:
There was a correlation between the level of serum BUN and salivary urea in controls and patients, which was statistically significant for controls (p=0.028).The correlation between serum and salivary Cr was 0.195 in controls (p=0.398) and 0.598 in patients (p=0.006), which was statistically significant in patients. The correlation between serum and saliva was 0.133 (p=0.566) in controls and 0.078 (p=0.737) in patients, which was not statistically significant. The correlation between serum BUN and β2-M was 0.168 (p=0.469) in the control group and 0.629 (p=0.002) in patients, which was statistically significant in patients. The correlation between serum Cr and β2-M was 0.110 (p=0.635) in the control group and 0.678 (p=0.001) in patients, which was statistically significant in patients. The correlation between serum BUN and salivary β2-M was 0.093 (p=0.0690) in controls and 0.152 (p=0.152) in patients, which was not statistically significant. The correlation between serum Cr and salivary β2-M was 0.072 (p=0.070) in the control group and 0.286 (p=0.209) in patients, which was not statistically significant in either group.
Conclusion:
The results of the study indicated that salivary β2-M cannot be used as a noninvasive indicator to detect the severity of renal failure.
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