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Direct Renin inhibitor: aliskiren in chronic kidney disease

Yoshiyuki Morishita1, Eiji Kusano

  • 1Division of Nephrology, Department of Medicine, Jichi Medical University, Tochigi, Japan.

Nephro-Urology Monthly
|April 12, 2013
PubMed

Insights

Aliskiren, a direct renin inhibitor, may effectively manage chronic kidney disease (CKD) and its complications by blocking the renin-angiotensin-aldosterone system (RAAS). This review examines aliskiren

Area of Science:

  • Nephrology
  • Cardiovascular Medicine
  • Pharmacology

Background:

  • The renin-angiotensin-aldosterone system (RAAS) is implicated in chronic kidney disease (CKD) progression.
  • RAAS activation contributes to hypertension (HT) and cardiovascular diseases (CVD), common CKD complications.

Purpose of the Study:

  • To review the effects of aliskiren, a direct renin inhibitor, on chronic kidney disease (CKD).
  • To evaluate aliskiren's potential in managing CKD and associated complications like hypertension and CVD.

Main Methods:

  • Literature review of studies investigating aliskiren's impact on CKD.
  • Analysis of aliskiren's mechanism as a direct renin inhibitor within the RAAS.

Main Results:

  • Aliskiren effectively blocks the renin-angiotensin-aldosterone system (RAAS).
  • Evidence suggests aliskiren's potential efficacy in managing chronic kidney disease (CKD).
  • Aliskiren may help mitigate complications such as hypertension (HT) and cardiovascular diseases (CVD).

Conclusions:

  • Aliskiren demonstrates promise as a therapeutic agent for chronic kidney disease (CKD).
  • Targeting the renin-angiotensin-aldosterone system (RAAS) with aliskiren may improve outcomes for CKD patients.

Keywords:
AliskirenBlood PressureCardiovascular DiseasesKidney Failure, ChronicRenin-Angiotensin System

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