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Rapid assays for Gaucher and Hurler diseases in dried blood spots using digital microfluidics
Ramakrishna S Sista1, Tong Wang, Ning Wu
1Advanced Liquid Logic, Inc., Research Triangle Park, NC 27709, USA.
Objective:
Easy tool for newborn screening of Gaucher and Hurler diseases.
Methods:
Method comparison between fluorometric enzymatic activity assay on a digital microfluidic platform and micro-titer plate bench assay was performed on normal (n = 100), Gaucher (n = 10) and Hurler (n = 7) dried blood spot samples.
Results:
Enzymatic activity analysis of glucocerebrosidase (Gaucher) and α-l-iduronidase (Hurler) revealed similar discrimination between normal and affected samples on both platforms.
Conclusions:
Digital microfluidics is suitable for Gaucher and Hurler newborn screening.
