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Protocol for Long Duration Whole Body Hyperthermia in Mice
Published on: August 25, 2012
Perspective on fever: the basic science and conventional medicine
1College of Allied Health Sciences, Georgia Health Sciences University, Augusta, GA 30912, USA. jcannon@georgiahealth.edu
Abstract:
This review describes how fever is generated as a regulated increase in body temperature. It results from an upward shift in the thermoregulatory set point, mediated by pyrogenic cytokines released from monocytes/macrophages in response to infection or trauma. Evidence will be presented that fever is part of an integrated host defense system, and that failure to generate a fever in response to infection is generally associated with a poorer prognosis.
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