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Updated: May 12, 2026
08:04
Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation
Published on: July 9, 2014
Vaccine against herpes zoster
1Hospital Israelita Albert Einstein, São Paulo, SP, Brasil.
Einstein (Sao Paulo, Brazil)
|April 13, 2013
Summary
The live attenuated varicella/zoster virus vaccine is generally safe and effective for preventing herpes zoster. While most side effects are mild injection site pain, it can prevent serious complications in at-risk individuals.
Area of Science:
- Immunology
- Virology
- Vaccinology
Background:
- Herpes zoster (shingles) is a debilitating condition caused by the varicella-zoster virus (VZV).
- Effective prevention strategies are crucial due to the high morbidity associated with VZV reactivation.
Purpose of the Study:
- To evaluate the safety and efficacy of the live attenuated varicella/zoster virus vaccine.
- To assess the potential complications and benefits of VZV vaccination.
Main Methods:
- The herpes zoster vaccine utilizes high doses of live attenuated varicella/zoster virus.
- Clinical data on vaccine tolerability and adverse events were reviewed.
Main Results:
- The vaccine is well-tolerated with minimal adverse effects, primarily injection site pain.
- Complications are rare, mainly observed in individuals with a history of zoster keratitis or uveitis.
Conclusions:
- The live attenuated varicella/zoster virus vaccine is a safe and effective method for preventing herpes zoster.
- Vaccination is recommended to mitigate the high morbidity associated with this viral disease, especially in susceptible populations.
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