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Stem Cell Transplantation in an in vitro Simulated Ischemia/Reperfusion Model

Stem Cell Transplantation in an in vitro Simulated Ischemia/Reperfusion Model

Published on: November 5, 2011

Stem cell transplant: An experience from eastern India.

A Mukhopadhyay¹, P Gupta, J Basak

¹Department of Haemato-Oncology, Molecular Biology and Bone Marrow Transplant Unit, Netaji Subhas Chandra Bose Cancer Research Institute, Kolkata, West Bengal, India.

Indian Journal of Medical and Paediatric Oncology : Official Journal of Indian Society of Medical & Paediatric Oncology

|April 13, 2013

Summary

This summary is machine-generated.

This study reports the first stem cell transplants in eastern India, achieving high survival rates for various hematological conditions. Bone marrow is recommended over cord blood for thalassemia, but cord blood is effective for aplastic anemia.

Keywords:

Aplastic anemia bone marrow transplantation cord blood transplantation eastern Indian data stem cell transplantation thalassaemia

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Isolation and Transplantation of Hematopoietic Stem Cells (HSCs)

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Published on: February 25, 2007

Area of Science:

Hematology
Transplant Immunology

Background:

Hematopoietic stem cell transplantation (HSCT) is a vital treatment for hematological malignancies, genetic disorders, and immune deficiencies.
While HSCT has been performed in India since 1983, eastern India lacked such facilities until this study.
This research marks the first report of HSCT in eastern India.

Purpose of the Study:

To establish and report the initial outcomes of hematopoietic stem cell transplantation in eastern India.
To evaluate the efficacy of different stem cell sources and conditioning regimens.

Main Methods:

Conducted 22 HSCTs between August 2000 and June 2011, including allogeneic and autologous transplants.
Patient indications included aplastic anemia, thalassemia, leukemia, lymphoma, and neuroblastoma.
Utilized bone marrow, peripheral blood stem cells, and umbilical cord blood as stem cell sources, with myeloablative or immunosuppressive conditioning.

Main Results:

Achieved a disease-free survival of 68.18% and an overall survival of 86.3% at a median follow-up of 4.6 years.
Common post-transplant complications included mucositis, infections, veno-occlusive disease, graft-versus-host disease, and hemorrhagic cystitis.
Identified specific outcomes based on stem cell source and patient indication.

Conclusions:

Bone marrow stem cells are superior to cord blood for thalassemia treatment in this region.
Related and unrelated cord blood proved effective for aplastic anemia and immunological disorders.
Successful establishment of HSCT services in eastern India, offering hope for patients with severe hematological conditions.