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Updated: May 12, 2026

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Published on: June 21, 2024
Imaging spectrum of primary malignant renal neoplasms in children
Rama Anand1, Mahender K Narula, Isha Gupta
1Department of Radiodiagnosis, Lady Hardinge Medical College and Associated Smt. Sucheta Kriplani and Kalawati Hospitals, New Delhi, India.
Insights
Wilms tumor is a common childhood abdominal cancer. Differentiating it from other pediatric renal tumors requires careful review of imaging, clinical presentation, and pathology for accurate diagnosis and prognosis.
Area of Science:
- Pediatric Oncology
- Diagnostic Imaging
- Renal Pathology
Background:
- Wilms tumor (WT) is the most frequent abdominal malignancy in children.
- Recent advancements recognize specific pediatric renal tumors beyond WT.
- Accurate diagnosis impacts treatment and patient outcomes.
Purpose of the Study:
- To review imaging features of pediatric malignant renal neoplasms.
- To correlate imaging findings with clinical presentation and pathology.
- To aid in differentiating various pediatric renal tumors.
Main Methods:
- Review of imaging characteristics of primary malignant renal tumors in children.
- Correlation of imaging findings with clinical and pathological data.
- Literature synthesis of diagnostic criteria.
Main Results:
- Distinct imaging features can suggest specific diagnoses.
- Age and clinical presentation are crucial diagnostic aids.
- Histological examination remains definitive for many cases.
Conclusions:
- Imaging plays a vital role in the pre-operative work-up of pediatric renal masses.
- Differentiating WT from other renal tumors is essential for appropriate management.
- Multidisciplinary approach combining imaging, clinical, and pathological data ensures optimal diagnosis.
Abstract:
Wilms' tumor (WT) is the most common abdominal tumor in children. Many pediatric renal tumors in the past were categorized as WT; however, in recent years, several specific renal tumors have been recognized as distinct pathological entities. The age and clinical presentation of the child and distinctive imaging features may help in reaching a specific diagnosis in most cases. This is important as it has implications on the pre-operative diagnostic work-up and prognosis of the child. However, it is often not possible to differentiate one from the other pediatric renal tumor on the basis of imaging alone, and the final diagnosis is often made at histological examination of the surgical specimen. This article reviews the imaging features of primary malignant renal neoplasms in children along with their clinical presentation and pathological features.
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