Related Experiment Video
Updated: May 12, 2026

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
Published on: September 5, 2017
Idiopathic infantile hypercalcemia or an extrapulmonary complication of tuberculosis?
Resul Yılmaz1, Ahmet Afşin Kundak, Taner Sezer
1Department of Children's Health and Diseases, Faculty of Medicine, Gaziosmanpasa University, Tokat, Turkey. drresul@hotmail.com
Insights
Severe hypercalcemia in infants can be life-threatening. This case highlights miliary tuberculosis as a rare but critical cause of hypercalcemia in a seven-month-old infant.
Area of Science:
- Pediatrics
- Endocrinology
- Infectious Diseases
Background:
- Calcium metabolism disturbances are frequent in childhood, with hypercalcemia presenting diverse etiologies in infancy.
- Common causes include hyperparathyroidism, familial hypocalciuric hypercalcemia, and iatrogenic factors like total parenteral nutrition.
- Rarer causes involve granulomatous disorders, such as tuberculosis and sarcoidosis, which pose significant health risks.
Abstract:
Calcium metabolism disturbances are common in childhood. In infancy, hypercalcemia generally occurs due to hyperparathyroidism, familial hypocalciuric hypercalcemia, subcutaneous fat necrosis, total parenteral nutrition administration, hyperthyroidism, and adrenal insufficiency. Granulomatous disorders such as tuberculosis and sarcoidosis are rarer cause of hypercalcemia. Hypercalcemia outcomes including nephrocalcinosis, brain, eye, artery calcifications and encephalopathic features are life-threatening. We report a seven-month-old girl with miliary tuberculosis who presented with severe hypercalcemia.
Related Concept Videos
Pulmonary Tuberculosis III
The first classification is based on the development of the disease, and it includes the following categories:
Pulmonary Tuberculosis II
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Pulmonary Tuberculosis IV
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Pulmonary Tuberculosis I
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Pulmonary Tuberculosis V
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...
Atypical Pneumonia