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Updated: May 12, 2026

Cell Co-culture Patterning Using Aqueous Two-phase Systems

Cell Co-culture Patterning Using Aqueous Two-phase Systems

Published on: March 26, 2013

Patchy surfaces stabilize dextran-polyethylene glycol aqueous two-phase system liquid patterns.

Taisuke Kojima¹, Shuichi Takayama

¹Department of Macromolecular Science and Engineering, University of Michigan, Ann Arbor, Michigan 48109, United States.

Langmuir : the ACS Journal of Surfaces and Colloids

|April 16, 2013

Summary

This summary is machine-generated.

Chemically heterogeneous surfaces enable stable patterning of aqueous two-phase system (ATPS) droplets on poly(dimethylsiloxane) (PDMS). This breakthrough allows for arbitrary dextran (DEX) solution patterning, advancing microfluidic applications.

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Area of Science:

Biomaterials Science
Surface Chemistry
Microfluidics

Background:

Aqueous two-phase systems (ATPS) are crucial for bioseparations.
Stable patterning of ATPS droplets on poly(dimethylsiloxane) (PDMS) surfaces is challenging.
Surface chemistry significantly influences droplet behavior in microfluidic devices.

Purpose of the Study:

To investigate the effect of surface chemistry on the stable patterning of ATPS droplets on modified PDMS.
To determine optimal surface modifications for reliable droplet placement and retention.
To achieve arbitrary patterning of dextran (DEX) solutions using chemically heterogeneous surfaces.

Main Methods:

PDMS surfaces were chemically modified with primary amine, carboxylic acid, and neutral groups.
Surface characterization included fluorescence measurements, contact angle analysis (water and DEX), and X-ray photoelectron spectroscopy (XPS).
ATPS droplets formed using polyethylene glycol (PEG) and DEX were patterned on modified PDMS substrates.

Main Results:

Homogeneous surfaces with different functional groups showed limited control over DEX droplet pinning.
Chemically heterogeneous (patchy) surfaces demonstrated significantly enhanced stability for patterned ATPS droplets.
Arbitrary patterning of DEX solutions was successfully achieved on chemically patchy PDMS surfaces.

Conclusions:

Surface chemical heterogeneity is key to achieving stable patterning of ATPS droplets on PDMS.
Chemically patchy surfaces offer a robust platform for controlled microfluidic applications involving ATPS.
This work provides a foundation for advanced microfluidic device design utilizing selective surface interactions.