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Updated: May 12, 2026
07:28
Donor Posterior Atrial Flap Rotation for Left Atrial Cuff Reconstruction in Lung Transplantation
Published on: October 11, 2024
Leg weakness in a lung transplant patient
T Moua1, S A Rizza, C C Kennedy
1Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN 55905, USA. moua.teng@mayo.edu
Summary
Progressive multifocal leukoencephalopathy (PML) in lung transplant patients is a rare but serious JC polyomavirus (JCV) reactivation. Management is challenging due to limited therapies and risks of graft rejection when reducing immunosuppression.
Area of Science:
- Neuroscience
- Infectious Diseases
- Transplantation Immunology
Background:
- Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system caused by JC polyomavirus (JCV).
- JCV reactivation typically occurs in immunosuppressed individuals, including those with HIV/AIDS, hematological malignancies, and solid organ transplant recipients.
- PML presents with focal neurologic deficits and is often diagnosed via neuroimaging and brain biopsy.
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