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Semi-Targeted Ultra-High-Performance Chromatography Coupled to Mass Spectrometry Analysis of Phenolic Metabolites in Plasma of Elderly Adults

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Does overall diet in midlife predict future aging phenotypes? A cohort study.

Tasnime Akbaraly¹, Séverine Sabia, Gareth Hagger-Johnson

¹Department of Epidemiology and Public Health, University College London, London, UK. tasnime.akbaraly@inserm.fr

The American Journal of Medicine

|April 16, 2013

Summary

Midlife diet quality, assessed by the Alternative Healthy Eating Index (AHEI), impacts healthy aging. A Western diet pattern was linked to lower odds of ideal aging, highlighting diet

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Area of Science:

Nutritional Epidemiology
Gerontology
Public Health

Background:

Extensive research links diet to specific age-related diseases, but few studies adopt a holistic view of diet's association with overall health in older adults.
This study investigates the association between midlife dietary patterns and adherence to the Alternative Healthy Eating Index (AHEI) with aging phenotypes after a 16-year follow-up.

Purpose of the Study:

To examine the association between midlife diet quality and subsequent aging phenotypes.
To determine if dietary patterns and adherence to the AHEI in midlife predict ideal aging outcomes later in life.

Main Methods:

Utilized data from the Whitehall II cohort study, including 5350 adults (mean age 51.3 years).
Dietary intake was assessed at baseline (1991-1993).
Aging phenotypes were defined by mortality, chronic diseases, and functioning assessments over a 16-year follow-up period, including ideal aging, cardiovascular events, and mortality.

Main Results:

Low adherence to the AHEI was associated with increased risk of both cardiovascular and noncardiovascular death.
A 'Western-type' diet, high in processed foods, red meat, and refined grains, was associated with significantly lower odds of achieving ideal aging (OR=0.58, P=.02), independent of other health behaviors.

Conclusions:

Dietary patterns in midlife are significantly associated with diverse aging phenotypes, including ideal aging and mortality.
Adherence to healthy eating patterns, like the AHEI, may promote healthier aging trajectories.
The study provides a novel perspective on diet's role in overall aging health by considering a composite of physiological and cognitive functions.