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Published on: June 6, 2025
A crucial role for Lyn in TIMP-1 erythroid cell survival signalling pathway
Lucie Bridoux1, Nicolas Etique, Elise Lambert
1Université de Reims Champagne Ardenne, CNRS FRE 3481 MEDyC, Laboratoire SiRMa, SFR CAP Santé, Moulin de la Housse, BP 1039, 51687 Reims, France.
Abstract:
TIMP-1, a well-known MMP inhibitor, displays other biological activities such as cell survival, proliferation and differentiation in hematopoietic cells. In this report, we investigated the role of the Src-related kinase Lyn in TIMP-1 induced UT-7 erythroleukemic cell survival. We showed that (i) tyrosine 507 of Lyn was dephosphorylated and Lyn kinase activity enhanced by TIMP-1, (ii) Lyn silencing suppressed TIMP-1 anti-apoptotic activity and (iii) Lyn was activated upstream the JAK2/PI 3-kinase/Akt pathway. Our data suggest a novel role for Lyn in erythroid cell survival.
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