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Updated: May 12, 2026

Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence
12:08

Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence

Published on: May 22, 2013

A polymerase chain reaction-based approach for evaluation of telomere-associated sequences and interstitial telomeric

Eva Sýkorová1, Miloslava Fojtová, Vratislav Peška

  • 1Institute of Biophysics, Academy of Sciences of the Czech Republic, 612 65 Brno, Czech Republic. evin@ibp.cz

Analytical Biochemistry
|April 16, 2013
PubMed

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In eukaryotic DNA replication, a single-stranded DNA fragment remains at the end of a chromosome after the removal of the final primer. This section of DNA cannot be replicated in the same manner as the rest of the strand because there is no 3’ end to which the newly synthesized DNA can attach. This non-replicated fragment results in gradual loss of the chromosomal DNA during each cell duplication. Additionally, it can induce a DNA damage response by enzymes that recognize single-stranded DNA.
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