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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

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[Photodynamic therapy-trends and new developments].

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Methyl aminolevulinate daylight photodynamic therapy applied at home for non-hyperkeratotic actinic keratosis of the face or scalp: an open, interventional study conducted in Germany.

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Related Experiment Video

Updated: May 12, 2026

An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model
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An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model

Published on: January 13, 2023

[New developments in photodynamic therapy].

E Kohl1, S Karrer

  • 1Klinik und Poliklinik für Dermatologie, Universitätsklinikum Regensburg, Franz-Josef-Strauss-Allee 11, 93042 Regensburg, Germany.

Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete
|April 16, 2013
PubMed
Summary
This summary is machine-generated.

Photodynamic therapy (PDT) advancements include new photosensitizers and laser techniques for actinic keratoses. PDT also shows skin rejuvenation benefits and efficacy in high-risk organ transplant recipients.

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Area of Science:

  • Dermatology
  • Photomedicine
  • Oncology

Context:

  • Recent advancements in photodynamic therapy (PDT) have expanded its therapeutic applications.
  • New photosensitizers, including 5-aminolevulinic acid (ALA) in patch and nanoemulsion forms, are now approved.
  • Ablative fractional lasers improve photosensitizer penetration for enhanced PDT efficacy.

Purpose:

  • To review recent developments in photodynamic therapy.
  • To highlight new PDT agents and techniques.
  • To discuss the efficacy and mechanisms of PDT for various dermatological conditions.

Summary:

  • Two new 5-aminolevulinic acid (ALA) formulations (self-adhesive patch, nanoemulsion) approved for actinic keratoses treatment since 2009.
  • Pre-treatment with fractional lasers enhances photosensitizer penetration, intensifying PDT for acral lesions and field-cancerized skin.
  • Clinical trials confirm PDT's skin-rejuvenating effects and clarify its mechanisms of action.
  • PDT demonstrates efficacy in treating and preventing actinic keratoses in organ transplant recipients.
  • Studies on daylight-mediated PDT are also summarized.

Impact:

  • PDT offers improved treatment options for actinic keratoses and precancerous skin conditions.
  • The findings support PDT's role in skin cancer prevention and management, particularly in immunocompromised individuals.
  • Understanding PDT's rejuvenating effects opens avenues for cosmetic and therapeutic applications.