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Obstructive sleep apnea and delirium: exploring possible mechanisms
Aibek E Mirrakhimov1, Carey L Brewbaker, Andrew D Krystal
1Department of Internal Medicine, Saint Joseph Hospital, Chicago, IL, USA, amirrakhimov1@gmail.com.
Obstructive sleep apnea (OSA) is linked to postoperative delirium. This study suggests OSA is a risk factor, recommending pre-surgical screening for OSA and related factors to potentially reduce delirium incidence.
Area of Science:
- Medical Science
- Sleep Medicine
- Neurology
Background:
- Obstructive sleep apnea (OSA) is linked to comorbidities and postoperative complications.
- OSA may cause systemic inflammation, oxidative stress, and neuronal apoptosis.
- OSA is associated with cognitive dysfunction and reduced brain activation.
Purpose of the Study:
- To investigate the association between obstructive sleep apnea (OSA) and delirium.
- To highlight OSA as a potential risk factor for postoperative delirium.
Main Methods:
- Review of existing literature and case reports.
- Analysis of a prospective study on OSA and delirium after knee replacement surgery.
Main Results:
- Case reports suggested a link between OSA and delirium.
- A prospective study found OSA independently associated with postoperative delirium after knee replacement.
Conclusions:
- Obstructive sleep apnea (OSA) should be considered a risk factor for delirium.
- Pre-surgical assessment for OSA and related factors is recommended.
- Further research is needed to understand the mechanisms and treatment effects.
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