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Updated: May 12, 2026
06:53
A Simple Alternative to Stereotactic Injection for Brain Specific Knockdown of miRNA
Published on: December 26, 2015
Viral delivery of small-hairpin RNAs for reducing gene expression in the rodent brain
Amy W Lasek1, Ulrike Heberlein
1Ernest Gallo Clinic and Research Center at the University of California at San Francisco, Emeryville, California.
Abstract:
This article reviews a strategy to ensure long-term expression of a type of interfering RNA molecule-small-hairpin RNAs (shRNAs)-through the use of viral delivery systems (i.e., vectors). Expression of these shRNAs leads to the destruction of the intermediary molecules (i.e., messenger RNA [mRNA] molecules) generated during the expression of the target gene.
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