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Updated: May 12, 2026

Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation
Published on: May 30, 2020
House dust mite interactions with airway epithelium: role in allergic airway inflammation
Vivek D Gandhi1, Courtney Davidson, Muhammad Asaduzzaman
1Pulmonary Research Group, Department of Medicine, University of Alberta, 567 HMRC, Edmonton, AB T6G 2S2, Canada. vivekdip@ualberta.ca
Abstract:
House dust mite (HDM) allergens are the most prevalent allergens associated with asthma and rhinitis around the world. The mechanisms of allergic sensitization and allergic airway inflammation after exposure to HDM have been studied extensively, but many questions remain unanswered. Airway epithelial cells are the first line of defense against external antigens and are considered an important player in the development of allergic airway inflammation. Both genetic susceptibility to allergic sensitization and HDM composition play decisive roles in the outcome of HDM-epithelium interactions, especially regarding airway epithelial dysfunction and allergic inflammation. Interactions between HDM and the airway epithelium have consequences for both development of allergy and asthma and development of allergic airway inflammation. This review will describe in detail these interactions and will identify issues that require more study.
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