Related Experiment Video

Updated: May 12, 2026

Transpupillary-Guided Trans-Scleral Transplantation of Subretinal Grafts in a Retinal Degeneration Mouse Model
07:37

Transpupillary-Guided Trans-Scleral Transplantation of Subretinal Grafts in a Retinal Degeneration Mouse Model

Published on: January 26, 2024

Scaffolds and stem cells: delivery of cell transplants for retinal degenerations

Karl E Kador1, Jeffrey L Goldberg

  • 1Bascom Palmer Eye Institute and Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, 1501 NW 10th Avenue, BRB 826, FL 33136, USA.

Expert Review of Ophthalmology
|April 16, 2013
PubMed

Insights

Stem cell therapy shows promise for retinal diseases by improving cell delivery and integration. Advances in tissue engineering and scaffold design are key to enhancing these treatments for photoreceptor and progenitor cells.

Area of Science:

  • Ophthalmology
  • Regenerative Medicine
  • Biomedical Engineering

Background:

  • Retinal degenerations and optic neuropathies cause cell death in the retina.
  • Photoreceptor and retinal ganglion cell loss leads to vision impairment.
  • Current stem cell therapies face challenges in cell delivery and integration.

Purpose of the Study:

  • To review advances in tissue engineering and cell scaffold design for retinal degeneration.
  • To focus on photoreceptor- and progenitor-directed stem cell approaches.
  • To highlight strategies for enhancing cell therapy efficacy in retinal diseases.

Main Methods:

  • Literature review of tissue engineering and cell scaffold design.
  • Analysis of stem cell delivery and integration techniques.
  • Focus on photoreceptor and progenitor cell therapies.

Main Results:

  • Tissue engineering and scaffold design offer improved methods for cell delivery.
  • Enhanced scaffolds promote better cell survival, integration, and function.
  • Preclinical models show promise, with human trials beginning.

Conclusions:

  • Advances in tissue engineering and scaffold design are crucial for successful stem cell therapy in retinal degeneration.
  • Optimized cell delivery and integration strategies are essential for therapeutic outcomes.
  • Further research in these areas will accelerate clinical translation for vision restoration.
Keywords:
photoreceptorprogenitor cellscaffoldstem celltissue engineeringtransplantation

More Related Videos

Sub-Retinal Delivery of Human Embryonic Stem Cell Derived Photoreceptor Progenitors in rd10 Mice07:46

Sub-Retinal Delivery of Human Embryonic Stem Cell Derived Photoreceptor Progenitors in rd10 Mice

Published on: October 6, 2023

Directed Induction of Retinal Organoids from Human Pluripotent Stem Cells06:38

Directed Induction of Retinal Organoids from Human Pluripotent Stem Cells

Published on: April 21, 2021

Related Concept Videos

iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...