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Related Concept Videos

Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
Blood Transfusion01:15

Blood Transfusion

Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
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A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
Acute Inflammation II: Local and Systemic Effects01:25

Acute Inflammation II: Local and Systemic Effects

Acute inflammation produces a coordinated set of local and systemic changes that limit injury, eliminate pathogens, and initiate repair. These responses arise within minutes of infection, trauma, or chemical insult and are driven by vascular alterations and leukocyte-derived mediators. When the stimulus resolves, the reaction typically abates within days.Local EffectsAt the site of injury, arteriolar vasodilation increases blood flow, resulting in redness and warmth. Simultaneously, increased...
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Inflammation

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Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
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The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Blood Typing01:10

Blood Typing

Understanding an individual's blood group is a critical component of transfusion medicine. It ensures compatibility in blood transfusions, organ transplants, and even during pregnancy. Determining these blood groups involves the ABO and Rh blood typing systems, utilizing specific antigens and corresponding anti-sera to identify an individual's blood type.
Antigens are protein molecules that reside on the surface of red blood cells (RBCs). The ABO and Rh blood typing systems target antigens A,...

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Fixed Volume or Fixed Pressure: A Murine Model of Hemorrhagic Shock
16:31

Fixed Volume or Fixed Pressure: A Murine Model of Hemorrhagic Shock

Published on: June 6, 2011

[Blood transfusion and inflammation].

O Garraud1, F Cognasse, H Hamzeh-Cognasse

  • 1Établissement français du sang (EFS) Auvergne-Loire, 25, boulevard Pasteur, 42023 Saint-Étienne cedex 2, France; GIMAP-EA3064, université de Lyon, 42023 Saint-Étienne, France. olivier.garraud@efs.sante.fr

Transfusion Clinique Et Biologique : Journal De La Societe Francaise De Transfusion Sanguine
|April 17, 2013
PubMed
Summary
This summary is machine-generated.

Inflammation after labile blood product (LBP) transfusion can occur due to cell damage and activation during collection and storage. Understanding these inflammatory triggers is key to improving transfusion safety and reducing adverse events.

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Fixed Volume or Fixed Pressure: A Murine Model of Hemorrhagic Shock
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Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
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Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

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Area of Science:

  • Transfusion Medicine
  • Immunology
  • Cellular Biology

Background:

  • Transfusion of labile blood products (LBPs) can lead to inflammatory hazards, often without detectable antigen-antibody reactions.
  • While leukoreduction has decreased incidents linked to residual leukocytes, other factors contribute to transfusion-related inflammation.
  • Platelets and red blood cells can release inflammatory mediators due to collection, preparation, storage conditions, and cellular aging.

Purpose of the Study:

  • To review the primary and secondary components of LBPs.
  • To identify pro-inflammatory molecules associated with transfusion.
  • To enhance understanding of transfusion-linked inflammatory hazards for improved safety.

Main Methods:

  • Literature review of current 'State of the Art' in transfusion medicine.
  • Analysis of cellular and molecular mechanisms of inflammation in LBPs.
  • Synthesis of data on storage lesions, cell activation, and apoptosis.

Main Results:

  • Cellular damage and activation during LBP processing and storage are significant contributors to inflammation.
  • Platelets are potent sources of inflammatory mediators, even without external stimulation.
  • Storage lesions, cell aging, and apoptosis exacerbate inflammatory responses post-transfusion.

Conclusions:

  • Inflammation following LBP transfusion is multifactorial, involving cellular components and their activation states.
  • Knowledge of these inflammatory pathways is crucial for developing targeted safety interventions.
  • Reducing transfusion-related inflammation requires a comprehensive approach addressing collection, preparation, and storage protocols.