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Updated: May 12, 2026
06:08
A Novel Method: Super-selective Adrenal Venous Sampling
Published on: September 15, 2017
Single versus duplicate blood samples in ACTH stimulated adrenal vein sampling
Tanja Dekkers1, Mark J Arntz, Gert Jan van der Wilt
1Department of General Internal Medicine, Radboud University Nijmegen Medical Center, Geert Grooteplein Zuid 8, 6525 GA Nijmegen, The Netherlands. t.dekkers@aig.umcn.nl
Summary
Single blood samples during adrenal vein sampling (AVS) for primary aldosteronism reliably determine aldosterone secretion location. This simplifies the technically demanding procedure, reducing costs and potential complications.
Area of Science:
- Endocrinology
- Interventional Radiology
Background:
- Adrenal vein sampling (AVS) is crucial for subtyping primary aldosteronism.
- The procedure is technically challenging and expensive.
- Current practice involves duplicate blood samples per site.
Purpose of the Study:
- To evaluate if single blood samples in AVS yield the same diagnostic conclusions as duplicate samples.
- To assess the impact of single versus duplicate sampling on determining aldosterone secretion laterality.
Main Methods:
- Retrospective analysis of 96 AVS procedures (2005-2010).
- Comparison of diagnostic conclusions using single sample (A) versus average of duplicate samples (AB).
- Calculation of the number needed for duplicate sampling to prevent misclassification.
Main Results:
- High concordance (98-100%) between single and duplicate sample conclusions.
- Number needed to sample in duplicate was infinite or 48, depending on criteria.
- Minimal incremental benefit observed with duplicate sampling.
Conclusions:
- Single blood samples in AVS are reliable for diagnosing aldosterone secretion lateralization.
- Simplifying AVS to single samples can be considered, especially with technical difficulties.
- This approach may reduce procedure complexity and cost.
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