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Related Concept Videos

Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...

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Related Experiment Video

Updated: May 12, 2026

Quantification of Diabetes-induced Adherent Leukocytes in Retinal Vasculature
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Published on: January 24, 2025

Differentials and approach to leukocoria.

Nishita Patel1, Daniel J Salchow, Miguel Materin

  • 1Yale New Haven Hospital, USA. nishdpatel@gmail.com

Connecticut Medicine
|April 18, 2013
PubMed
Summary

Leukocoria, an abnormal white reflex in the eye, can indicate serious conditions like retinoblastoma or cataracts. The Brückner test aids in early detection, necessitating prompt ophthalmologist referral for suspected cases.

Area of Science:

  • Ophthalmology
  • Pediatric Medicine
  • Clinical Diagnostics

Background:

  • Leukocoria, a white pupillary reflex, is a critical sign of intraocular pathology.
  • Common causes include retinoblastoma and congenital cataracts, particularly in pediatric populations.
  • Early detection is crucial for effective management and visual prognosis.

Purpose of the Study:

  • To highlight the significance of leukocoria as a clinical finding.
  • To emphasize the utility of the Brückner test in assessing the red reflex.
  • To underscore the importance of timely referral for suspected leukocoria.

Main Methods:

  • Clinical examination focusing on pupillary red reflex assessment.
  • Utilizing the Brückner test as a rapid diagnostic tool.

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  • Review of common intraocular pathologies associated with leukocoria.

    • Main Results:

    • Leukocoria signifies potential serious intraocular conditions.
    • The Brückner test provides a simple and cost-effective method for red reflex evaluation.
    • Prompt ophthalmologist consultation is vital upon suspicion of leukocoria.

    Conclusions:

    • Leukocoria warrants immediate ophthalmological evaluation.
    • The Brückner test is a valuable bedside diagnostic aid.
    • Timely intervention can significantly impact outcomes for conditions like retinoblastoma and cataracts.